Semantic and Structural Difficulties with the Unified Modeling Language Use-Case Notation version 1.3

A case study was undertaken to examine and apply the UML use-case notation version 1.3. This study shows that the notation is open to interpretation and the semantics of the use-case relationships are confusing. The attempt to bolt on the object-oriented inheritance structure to the use-case notation is shown to cause problems with users

Heuristics for use case descriptions.

Use cases, as part of the Unified Modelling Language, have become an industry standard. The major focus has been on the use case diagram. It is only recently that any detailed attention has been paid to the use case description. The description should be written in such a way as to make it communicable to its reader. However, this does not always appear to be the case. This thesis presents the 7 C's of Communicability as quality features of use case descriptions that make them more comprehensible. The 7 C's are derived from software engineering best practice on use case descriptions and from theories of text comprehension. To help in writing descriptions, the CP Use Case Writing Rules are proposed, a small set of guidelines derived from the 7 C's. Going beyond requirements, software engineers often employ use case descriptions to help them build initial design models of the proposed system. Despite Jacobson's claim that "objects naturally fall out of use cases", fording design-oriented classes and objects in use case descriptions is shown not to be straightforward. This thesis proposes a Question Set which allows the engineer to interrogate the description for important elements of specification and design. Experimentation shows that the CP Writing Rules furnish descriptions that are as comprehensible as those written by other guidelines proposed in the literature. It is also suggested that descriptions be written from the perspective of their intended audience. The limitations of conducting requirements engineering experiments using students are considered and it is suggested that experimenters should not expect large effects from the results. An industrial case study shows that although the CP Rules could not be applied to all events in the use case descriptions, they were applied to most and at varying levels of abstraction. The case study showed that the 7 C's did identify problems with the written descriptions. The Question Set was well received by the case study stakeholders, but it was considered time consuming. One of the overriding findings from the case study was that project time constraints would not allow the company to use the techniques suggested, although they recognised the need to do so. Automation would make industrial application of the CP Rules and 7 C's more feasible

Whole genome metagenomic analysis of the gut microbiome of differently fed infants identifies differences in microbial composition and functional genes, including an absent CRISPR/Cas9 gene in the formula-fed cohort

Background: Advancements in sequencing capabilities have enhanced the study of the human microbiome. There are limited studies focused on the gastro-intestinal (gut) microbiome of infants, particularly the impact of diet between breast-fed (BF) versus formula-fed (FF). It is unclear what effect, if any, early feeding has on short- term or long-term composition and function of the gut microbiome. Results: Using a shotgun metagenomics approach, differences in the gut microbiome between BF (n = 10) and FF (n = 5) infants were detected. A Jaccard distance principle coordinate analysis was able to cluster BF versus FF infants based on the presence or absence of species identified in their gut microbiome. Thirty-two genera were identified as statistically different in the gut microbiome sequenced between BF and FF infants. Furthermore, the computational workflow identified 371 bacterial genes that were statistically different between the BF and FF cohorts in abundance. Only seven genes were lower in abundance (or absent) in the FF cohort compared to the BF cohort, including CRISPR/Cas9; whereas, the remaining candidates, including autotransporter adhesins, were higher in abundance in the FF cohort compared to BF cohort. Conclusions: These studies demonstrated that FF infants have, at an early age, a significantly different gut microbiome with potential implications for function of the fecal microbiota. Interactions between the fecal microbiota and host hinted at here have been linked to numerous diseases. Determining whether these non- abundant or more abundant genes have biological consequence related to infant feeding may aid in under- standing the adult gut microbiome, and the pathogenesis of obesity

A Sensitive Search for [N II]205 μm Emission in a z = 6.4 Quasar Host Galaxy

We present a sensitive search for the 3P1 → 3P0 ground-state fine structure line at 205 μm of ionized nitrogen ([N II]205μm) in one of the highest-redshift quasars (J1148+5251 at z = 6.42) using the IRAM 30 m telescope. The line is not detected at a (3σ) depth of 0.47 Jy km s^−1, corresponding to a [N II]205μm luminosity limit of L[N II] 7) using the Atacama Large Millimeter/submillimeter Array, for which the highly excited rotational transitions of CO will be shifted outside the accessible (sub-)millimeter bands

An Information Infrastructure For Sustainable IT Procurement: A Suitable Case For Actor-Network Theory?

The use of Actor-Network Theory (ANT) is assessed as a means of understanding the context of the information architecture needed to support sustainable procurement practices. The Higher Education (HE) Institutions within the UK public sector have been the subject of central government initiatives to fulfil the UK’s international obligations to reduce carbon emissions. This has included measures to introduce sustainability criteria into procurements decisions, which require staff to make decisions informed by the sustainability characteristics of the products available. This could include a wide range of data about the whole supply chain of a product, which could involve many different organisational entities. Previous research, particularly on the evolution of inter-organisational information infrastructures, suggested ANT as a research approach. The particular features of ANT that seemed to be particularly supportive of the understanding of the issues of IT sustainable procurement are presented along with examples of their application to the problem domain

A survey of diffuse interstellar bands in the Andromeda galaxy: optical spectroscopy of M31 OB stars

We present the largest sample to-date of intermediate-resolution blue-to-red optical spectra of B-type supergiants in M31 and undertake the first survey of diffuse interstellar bands (DIBs) in this galaxy. Spectral classifications, radial velocities and interstellar reddenings are presented for 34 stars in three regions of M31. Radial velocities and equivalent widths are given for the 5780 and 6283 DIBs towards 11 stars. Equivalent widths are also presented for the following DIBs detected in three sightlines in M31: 4428, 5705, 5780, 5797, 6203, 6269, 6283, 6379, 6613, 6660, and 6993. All of these M31 DIB carriers reside in clouds at radial velocities matching those of interstellar Na I and/or H I. The relationships between DIB equivalent widths and reddening (E(B-V)) are consistent with those observed in the local ISM of the Milky Way. Many of the observed sightlines show DIB strengths (per unit reddening) which lie at the upper end of the range of Galactic values. DIB strengths per unit reddening are found (with 68% confidence), to correlate with the interstellar UV radiation field strength. The strongest DIBs are observed where the interstellar UV flux is lowest. The mean Spitzer 8/24 micron emission ratio in our three fields is slightly lower than that measured in the Milky Way, but we identify no correlation between this ratio and the DIB strengths in M31. Interstellar oxygen abundances derived from the spectra of three M31 H II regions in one of the fields indicate that the average metallicity of the ISM in that region is 12 + log[O/H] = 8.54 +- 0.18, which is approximately equal to the value in the solar neighbourhood